Cells and prions: A license to replicate
نویسندگان
چکیده
منابع مشابه
Qualifying for the license to replicate
A single replication fork would take more than a year to replicate the genome of Xenopus. By dividing the task among many thousands of replicons, each replicated by forks emanating from individual origins, replication is instead completed in as little as 30 min. While this efficient strategy has been adopted by all eukaryotes, it introduces a complication. To maintain the integrity of the genom...
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Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades. In this paper, we show that astrocytes derived from human induced pluripotent stem cells (iPSCs) support the replication of prions from brain samples of CJD patients. Fo...
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Much of our knowledge of the basal mechanism underly-44 Lincoln's Inn Fields ing programmed cell death derives from the elegant London WC2A 3PX studies of Horvitz and colleagues on developmental cell United Kingdom death in the developmentally deterministic nematode worm Caenorhabditis elegans. During development of Apoptosis is the descriptive name given to the process the hermaphrodite worm, ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2009
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2009.06.014